VeloNews | Drug maker cooperated with WADA

The World Anti-Doping Agency said Wednesday Italian rider Riccardo Riccò tested positive at the Tour de France after a secret molecule was planted in the blood booster EPO during its manufacture.

Riccò, 24, upset the big names of the sport to win two stages of this year’s Tour before he was kicked off after testing positive for EPO (erythropoietin).

Revealing the now high-tech nature of the fight against drugs in sport, WADA chief John Fahey said his organization worked with drugs giant Roche on the newest version of EPO (erythropoietin).

He said Roche had included a molecule in the third generation of EPO, called Continuous Erythropoiesis Receptor Activator (CERA) that acted as a marker in drug tests.

“In the development of that particular substance, close cooperation occurred between WADA and the pharmaceutical company Roche Pharmaceuticals so that there was a molecule placed in the substance well in advance that was always going to be able to be detected once a test was taken,” Fahey told public radio in his native Australia.

Until this year’s Tour, CERA, which is released into the body more slowly than its predecessors, had been thought to be undetectable by drug testers.

Followers of sport have been calling for markers to be placed into certain performance-enhancing drugs for years, and it appears as though it’s finally happening.

In the United States, it would be nearly impossible to insert a marker into a drug after the fact, as it would have to go through the entire testing and approval process from the FDA all over again, which is why Epogen^® and Aranesp^® (Amgen’s EPO drugs) have taken so long to become detectable; they weren’t designed with the markers already built in, so the drug-testers had to devise another way.

But Mircera^® (the brand-name for CERA) was developed with the marker already built in; a fact that surely would have been disclosed to the approvers, and obviously to WADA, but not widely spread, especially to the athletes. And what better way to catch the cheaters than to not tell them HOW you’re going to catch them.

This is the right way to catch drug cheats; not witch hunts.

Yeah, Floyd Landis likely doped. He still got screwed by a system which admits no wrong … and the system still has a lot of other problems. Now that Dick Pound is no longer pounding his dick at WADA, their organizational issues should get better. It’s too bad he’s now a part of the Court of Arbitration for Sport, but one step at a time … and we’ll clean up both the sport and the governing bodies.

VeloNews | Riccardo Ricco tests positive.

The French anti-doping agency (AFLD) confirmed Thursday that Italian climbing sensation Ricardo Ricco (Saunier Duval) has tested positive for new variant of the blood booster erythropoietin (EPO).

Ricco, winner of two mountain stages and ninth in the overall standings, provided a urine sample which contained the banned substance CERA (Continuous Erythropoiesis Receptor Activator).

Ricco was questioned by gendarmes before the start of Thursday’s 12th stage between Lavlanet and Narbonne. He was then driven away by them in a Saunier Duval team car.

Ricco was one of the riders particularly targeted by the AFLD during the race and had been tested at least four times, including his victories on stages six and nine.

Like synthetic erythropoietin (rEPO), CERA was developed to as a treatment for the anemia that results from chronic kidney disease. Unlike single injections of rEPO, CERA interacts with erythropoietin receptors and has a longer-lasting effect.

The often brash and outspoken Ricco finished second in this year’s Giro d’Italia and has won stages six and nine at this year’s Tour de France. He finished Wednesday’s stage 2:29 behind Australian Cadel Evans in the overall standings, putting him in ninth place.

Ricco becomes the third rider to fail a doping test in this year’s race after Spanish riders Moises Duenas (Barloworld) and Manuel Beltran (Liquigas) both tested positive for rEPO.

Much was made of the fact that Ricardo Ricco worshiped Marco Pantani, and he certain climbed like the now dead Italian. Now it appears that Ricco’s legs were not entirely natural talent …

Now, while I’m not sure about ASO and AFLD’s tactic of testing a rider over and over and over again, as it comes across as a witchhunt … sometimes, when what you’re seeing seems too good to be true, it probably is. If this sport is to survive, we need to get rid of the dopers, but it has to be done in a way that protects the rights of the riders.

More news from around the net:

• BBC
• The (London) Times
• The Guardian

From the New York Times:

Study Shows Problems With Olympic-Style Tests

Although athletes have said EPO is in widespread use, few have tested positive. Most of the athletes who have been linked to doping in recent years have been caught not through drug testing, but rather through criminal investigations. In the August 2006 issue of the journal Blood, the American lab accredited to conduct EPO testing reported only 9 positive tests out of 2,600 urine samples.

The new study may help explain why: the test simply failed.

The study, to be published Thursday in the online edition of the Journal of Applied Physiology, was conducted last summer and fall by a renowned lab in Denmark, the Copenhagen Muscle Research Center. The investigators gave eight young men EPO and collected urine samples on multiple occasions before, during and after the men were doping. The men’s urine samples were then sent to two labs accredited by the World Anti-Doping Agency, and EPO tests were requested.

The first lab found some samples positive and a few others suspicious. (A suspicious result does not bring sanctions for doping.) The lab also declared a sample positive, although the man had stopped taking the drug and it should have been gone from his urine. His previous urine sample, obtained when he was taking EPO, was negative in this lab’s test.

The second lab did not deem any urine sample positive for EPO and found only a few to be suspicious. The two labs did not agree on which samples were suspicious.

… [Investigators] realized they had an opportunity to investigate the validity of the EPO test. So, without telling the anti-doping labs what they were doing, the investigators sent the men’s urine samples for EPO testing.

One of the two labs, which the researchers refer to as Lab B in their paper, never declared a sample positive, even when the men were taking high doses of EPO every other day. Lab A was inconsistent. It found EPO during the high dose phase. But in the maintenance phase, it found EPO in only 6 of the 16 samples.

Great news, eh?

Not like “I never tested positive” meant a whole lot before, but with this news, anyone who claims not to have doped and “never testing positive” can have the “yeah, but the tests detect it every time” argument thrown back at them …

And clean athletes will never be able to prove that they haven’t doped … all winning riders are going to fall under suspicion.

“You won the race? You must have doped.”

From www.cyclingnews.com - the world centre of cycling:

Neben, others sue Hammer Nutrition over contamination
Mark Zalewski, North American Editor

American cyclist Amber Neben, along with professional triathletes Rebekah Keat and Mike Vine, filed a lawsuit in a California district court last December against Hammer Nutrition, maker of Endurolytes. The lawsuit alleges that the product contained unlisted substances that caused all three plaintiffs to produce positive doping tests, and that further resulted in subsequent doping violations and sanctions.

Court documents obtained by Cyclingnews state that each plaintiff took multiple capsules of the product Endurolytes before competing in events in which each subsequently tested positive for 19-norandrosterone, a metabolite of the banned steroid norandrostenedione found in urine. Arguing for the plaintiffs is Howard Jacobs, well known for his work with Floyd Landis’ case as well as other professional athletes involved with doping violations.

The lawsuit, which was initiated by Keat and her twin-sister Simone, states that Simone had the capsules in question independently tested by the WADA-accredited Doping Control Centre lab in Malaysia in June of 2006, all before retaining Jacobs. That lab reported to Keats that the capsules contained dehydroepiandrosterone and 4-androstenedione. Upon further examination, after repeated requests by Keat, the lab also found the samples were contaminated with norandrostenedione.

Hammer Nutrition’s response:

Response to Athlete Lawsuit

(WHITEFISH, MT) On January 23, 2008, Hammer Nutrition LTD. was served with a lawsuit filed by three athletes. The complaint alleged that a Hammer Nutrition product used by the athletes, specifically Endurolytes, was contaminated with banned substances which led to the athletes’ positive drug tests in 2002-2004.

On February 11, 2008, the plaintiffs issued a press release. It is unfortunate that the plaintiffs have decided to take their case to the court of public opinion. We trust that the media and the public will allow due process and the courts to deal with this matter before rushing to judgment. While we empathize with the challenges that these three athletes face by virtue of their positive drug tests, they are directing the blame for their situation in the wrong direction. We are certain that when all of the facts are presented in a court of law, Hammer Nutrition LTD. will be vindicated of any wrong doing.

It will be interesting to see where this one goes … it would also be nice to see Hammer put out a statement of some sort indicating that controls are in place to ensure that current manufacturing procedures do not allow any cross-contamination … my guess, however, is that their attorneys are telling them that would be tantamount to an admission that at the time the alleged contamination occurred they did NOT have any controls in place; because, of course, that’s the way that lawyers think.

2008 Teams Announced | Amgen Tour of California

I cannot believe that the organizers have invited (Crack) Rock Racing to participate in the Amgen Tour of California …

This is a team that has hired alleged (and in at least one rider’s case, convicted) dopers like Santiago Botero, Oscar Sevilla, and Tyler Hamilton. This is a team that is actively consorting with a rider that is currently banned from the sport for a doping violation (in Floyd Landis). This is a team that is losing sponsors (HED for sure, and others are rumored) because of these associations.

Ah, but this is also a team that signed on as a “founding sponsor” of the Amgen Tour of California itself … I guess when you buy your way into a race, it wouldn’t really be cool to exclude the team.

But with all the ridicule that Amgen, makers of the most widely abused performance-enhancing drug, has taken for sponsoring a race, why not add a team that seemingly turns a blind eye to doping to the mix as well.

And people wonder why this sport is going to hell in a handbasket.

I know Sager has got at least one compadre on the squad, and there are a lot of other good riders on the team; but Michael Ball reminds me of John Wordin (and the whole Mercury/Viatel fiasco) … and I’ll feel sorry for the rank-and-file riders when the team implodes mid-season.

And I really hope I’m wrong, for their sake.